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BIOL 474: Biology of Global Health

Knowledge Syntheses - Differences and Similarities

The following table, developed by the University of Toronto Libraries, displays the similarities and differences between the most common types of reviews. This table was adapted from a variety of sources (Booth, 2016Grant and Booth, 2009Higgins & Green, 2011Pham et al., 2014; and Tricco et al., 2015)

Knowledge synthesis 

A priori protocol required?

Protocol registration required? 

 Comprehensive  search?

Duplicate screening & data extraction?

Critical appraisal?

  Statistical analysis?

 Time 

Systematic Review

YES, often published

PROSPEROJBIOSF

YES

YES

YES

YES

1+ yr

Meta Analysis

YES, often published

PROSPEROJBIOSF

YES

 YES

YES

 YES

1+ yr

Scoping Review

YES

JBIOSFResearch Registry & other  registries

YES

YES

NO

NO, charted evidence

~ 1 yr

 Rapid Review

YES, often not published

OSFResearch Registry, & other registries

NO, varied # of databases, dates and other limits

Varied

NO, but recommended

 NO, varied analysis methods

 ~1 - 6 mo

 Realist Review

YES, some published

OSFResearch Registry, & other registries

YES

 YES

NO

NO

 1+ yr

 Overview of reviews

YES, often published

PROSPEROOSF, & other registries

 YES, only reviews included

 YES

YES

YES

 ~ 1 yr

Mapping Review

Encouraged

OSFResearch Registry, & other registries 

YES

 Varied

NO

NO

1+ yr 

Narrative Review

NO

Not necessary

Varied, not necessary

Varied, not necessary 

NO

NO

6 mo

- 1 yr 

Spotlight on Scoping Reviews

A scoping review is a literature review which maps the extent, range, or nature of research on a topic or question. It uses explicit, reproducible methods to identify all studies meeting pre-specified eligibility criteria to determine whether a systematic review is necessary, summarize available evidence, identify gaps in research, and plan for future research.

You should conduct a scoping review if you want:

  • To examine the extent, range and nature of research activity
  • To determine the value of undertaking a full systematic review
  • To summarize and disseminate research findings
  • To identify research gaps in the existing literature¹

Grey Literature

Grey literature is any material published outside of book and journal publishing. This includes most webpages, government documents, theses, corporate documents, reports, conference proceedings, online handbooks and manuals, and much more. Systematic and scoping reviews often include information from clinical trial registers, theses, and conference abstracts. Health technology assessments often include information from other HTA's or systematic reviews, economic reports, government regulatory information, clinical practice guidelines, etc.